Studies on Alzheimer's Disease

• 22 september 2013
• 9781627035972

Samenvatting:

This volume systematically reviews the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as “oxidative stress,” in the pathology of Alzheimer’s disease.

Dr. Domenico Praticò received his M.D. from the University of Rome “La Sapienza,” School of Medicine. He is currently a Professor of Pharmacology, Microbiology and Immunology and member of the Center for Translational Medicine at Temple University. His main research interest is oxidative biology with a particular focus on bioactive lipids, their metabolic pathways, and their role as biological mediators of cellular and molecular events in the pathogenesis of human diseases, including neurodegenerative and cardiovascular diseases.

Dr. Patrizia Mecocci received her M.D. from the University of Perugia, School of Medicine. She is currently a Full Professor of Gerontology and Geriatrics and Director of the Geriatric Clinic at the University of Perugia. Her research is devoted mainly to clinical geriatrics, with a specific interest on brain aging and dementia and on age-related biological modifications, with a particular focus on the role of oxidants and antioxidants in neurodegenerative and cardiovascular diseases.

This volume systematically reviews the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as “oxidative stress,” in the pathology of Alzheimer’s disease. It describes the most current diagnostic tools, laboratory methods and technology, and suggests ways of prevention and treatment to emphasize the concept of the bench-to-bedside approach. Studies on Alzheimer’s Disease provides thorough coverage of emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents, and several more relevant aspects. In addition, this book promotes the concept of using biomarkers representative of oxidative stress reactions and free-radical damageand describes the effects of antioxidants in treating disease in clinical trials. This content is invaluable to both researchers and clinicians studying the development of and treating patients with Alzheimer’s Disease.